Effect of Magnesium Sulfate Nebulization on Stress Response Induced Tracheal Intubation; Prospective, Randomized Study

Background and Aims: Multiple, nonpharmacological pharmacological measures have been used for attenuating stress response of intubation with variable results. N-methyl-D-aspartate (NMDA) receptors a role in nociception inflammation. NMDA are located peripheral the central nervous system. Magnesium is also receptor blocker. Aim Study: To evaluate effect nebulized magnesium sulfate on reduce induced tracheal Material Methods: Following institutional ethical committee approval written informed consent, prospective randomized double-blinded study was conducted 100 cases divided into two equal groups. Patients included were either gender belonging to American Society Anesthesiologists (ASA) status 1 or 2 undergoing elective surgery requiring intubation. will be recruited groups; Group A: receive 3 ml (240 mg) over 15 min. While group B: normal saline min, ending 5 min before induction anesthesia. SBP, DBP, HR, blood glucose level measured at following intervals; Baseline (before induction), after premedication (sedation), induction, ETT intubation, later, 6 later. Results: Preoperative nebulization has significant (p value Conclusion: significantly reduces